Results: The main dose monitors were set so that a certain amount of load was collected in the monitor chamber corresponding to a single MU, in accordance with the IAEA TRS 398 protocol, under a specific reference condition. The calibration method of the dose monitor is based on the absolute dose per MU, which is the absolute dose per particle used by other grid radius organisms. The full width for spot size in air ranges from about 1.2 cm for 221.8 MeV to 3.4 cm for 72.5 MeV. The depth dose of 90% measured in water corresponds to intervals between 4.0 and 30.6 cm. Irradiation locks work as intended and ensure the safe and accurate delivery of the intended dose. In addition to the new research and development agreement, Ziopharm has entered into a lease with MD Anderson, through which the company provides additional laboratory and office space on the institution`s campus. The new facility will serve as home to Ziopharm`s expanded Houston office, led by Eleanor de Groot, Ph.D., PPE, GM Cell Therapy and Drew Deniger, Ph.D., director of Ziopharm`s TCR-T cell therapy program. BOSTON and HOUSTON, Oct. 28, 2019 (GLOBE NEWSWIRE) — Ziopharm Oncology, Inc.
(“Ziopharm” or “the Company”) (Nasdaq:ZIOP) and the University of Texas MD Anderson Cancer Center today announced a new research and development agreement for Ziopharm`s sleeping pill immunotherapy program for non-viral gene transfer for stable formation and clinical evaluation of T-cell neoantogen receptors (TCR) in T cells (called T-TCR) designated individuals). As part of the transaction, Bellicum will also enter into a framework agreement with MD Anderson. Upon the transaction, MD Anderson will operate the Houston plant for its own in-house programs, as well as for the manufacture of Bellicums GoCAR™ and other cell therapy programs for clinical trials and possibly early commercial supply. Bellicum`s Houston headquarters will remain the center of excellence for our research, processes and analysis, third-party manufacturing and quality assurance. Under the new agreement, Ziopharm is committing to funding an additional $20 million by 2023 for this expanded work under the TCR-T program, as well as for certain milestone payments for clinical development or administrative authorization in the United States, the European Union, Japan and the rest of the world. Funding for this new agreement was included in Ziopharm`s budget forecast in the press release on the second quarter 2019 financial results and in the webcast commentary. “We are pleased to deepen our relationship with MD Anderson, which treats a large and diverse population of cancer patients with solid tumors,” said Laurence Cooper, M.D., Ph.D., Chief Executive Officer of Ziopharm. “This new agreement is a starting point to expand our TCR library and conduct two new clinical trials. a study on the use of library TCRs that target hotspot mutations in KRAS, TP53 and EGFR, and a second study for personalized TCRs that target patient-specific neoantogens. » Conclusions: The dosimetric parameters of the discrete spot-scanning proton beam were measured as part of the clinical commissioning program, and the machine operates safely and is therefore suitable for patient treatment. . . .